La tiña imbricata es una micosis superficial crónica causada por el hongo Trichophyton concentricum. Es endémica en América Central y del Sur, el Suroeste del Pacífico y el Sudeste Asiático, y afecta principalmente a las personas que viven en condiciones primitivas y en entornos aislados.Los pacientes suelen presentar una erupción concéntrica, con picazón, escamosa, que […]
Tinea imbricata is a chronic superficial mycosis caused by the fungus Trichophyton concentricum. A recent case report by Dr A Leung and colleagues describes a case of tinea imbricata in an 8 year old Malaysian boy.
Histoplasmosis is a fungal infection endemic to areas of Central America and Midwest USA. Most people develop a mild form of infection and are asymptomatic; if symptoms do occur they are usually flu-like, but can vary greatly. In a few, usually immunosuppressed, patients the disease can progress to life-threatening, disseminated histoplasmosis. Dr Thais Pincelli and colleagues recently reviewed all 10 cases of oropharyngeal histoplasmosis identified over a 21 year period at the Mayo Clinic in Rochester, Minnesota.
This week a team from the University of Manchester, London School of Hygiene and Tropical Medicine and GAFFI presented work at ECCMID showing the burden of fungal disease estimates for Namibia, Paraguay and Kyrgyzstan, and that fungal keratitis leads to over 600,000 blind eyes annually
In a recent study on coelomycetous fungi from clinical origin, Dr Garcia-Hermoso and colleagues  identified eight N. keratinophila isolates from superficial mycosis cases in Spain.
A collaboration between scientists in Manchester and Uganda reveals that around 1 in 15 tuberculosis patients go on to develop chronic pulmonary aspergillosis (CPA), via cavities left by the tuberculosis. Prompt diagnosis and antifungal treatment has the potential to save many thousands of lives.
MALDI-ToF mass spectrometry has proven useful in identifying bacteria in clinical samples, but the technology has lagged behind in its use for filamentous fungi. Dr Stein and colleagues in Canada compared three libraries (MSI, Bruker v1.0 and NIH) for their ability to identify clinical and reference strains.
Malassezia typically causes skin infections but can occasionally cause systemic disease, particularly in patients with indwelling devices such as central venous catheters. Dr Pedrosa and colleagues have published a literature review and three unrelated cases of systemic Malassezia at a hospital in Portugal.
Voriconazole can induce QTc prolongation and life-threatening arrhythmias. Dr Pasternak and colleagues in Israel found that QTcP >60 ms occurred in around a third of children receiving voriconazole. They recommend ECG monitoring for all patients, and correction of electrolyte imbalances (especially potassium) before initiating voriconazole treatment.
Safety and tolerability data for long-term use of fluconazole are scarce. Dr Davis and colleagues have published a study of 124 coccidioidomycosis patients in California and found that around half (52%) experienced significant side effects, in particular dry skin, hair loss and fatigue.