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Tiña imbricata: una micosis superficial rara

La tiña imbricata es una micosis superficial crónica causada por el hongo Trichophyton concentricum. Es endémica en América Central y del Sur, el Suroeste del Pacífico y el Sudeste Asiático, y afecta principalmente a las personas que viven en condiciones primitivas y en entornos aislados.Los pacientes suelen presentar una erupción concéntrica, con picazón, escamosa, que […]

Oropharyngeal histoplasmosis: a manifestation of disseminated disease

Histoplasmosis is a fungal infection endemic to areas of Central America and Midwest USA. Most people develop a mild form of infection and are asymptomatic; if symptoms do occur they are usually flu-like, but can vary greatly. In a few, usually immunosuppressed, patients the disease can progress to life-threatening, disseminated histoplasmosis. Dr Thais Pincelli and colleagues recently reviewed all 10 cases of oropharyngeal histoplasmosis identified over a 21 year period at the Mayo Clinic in Rochester, Minnesota.

ECCMID 2019 presentations: burden of fungal disease estimates for Namibia, Paraguay and Kyrgyzstan

This week a team from the University of Manchester, London School of Hygiene and Tropical Medicine and GAFFI presented work at ECCMID showing the burden of fungal disease estimates for Namibia, Paraguay and Kyrgyzstan, and that fungal keratitis leads to over 600,000 blind eyes annually

1 in 15 TB sufferers go on to develop chronic pulmonary aspergillosis, treatment could save 1000s

A collaboration between scientists in Manchester and Uganda reveals that around 1 in 15 tuberculosis patients go on to develop chronic pulmonary aspergillosis (CPA), via cavities left by the tuberculosis. Prompt diagnosis and antifungal treatment has the potential to save many thousands of lives.

Comparison of three MALDI-ToF libraries (MSI, Bruker, NIH) for identification of filamentous fungi

MALDI-ToF mass spectrometry has proven useful in identifying bacteria in clinical samples, but the technology has lagged behind in its use for filamentous fungi. Dr Stein and colleagues in Canada compared three libraries (MSI, Bruker v1.0 and NIH) for their ability to identify clinical and reference strains.

Indwelling catheters and immune disorders are risk factors for systemic Malassezia infection

Malassezia typically causes skin infections but can occasionally cause systemic disease, particularly in patients with indwelling devices such as central venous catheters. Dr Pedrosa and colleagues have published a literature review and three unrelated cases of systemic Malassezia at a hospital in Portugal.

Children receiving voriconazole should receive ECG monitoring and electrolyte imbalance correction

Voriconazole can induce QTc prolongation and life-threatening arrhythmias. Dr Pasternak and colleagues in Israel found that QTcP >60 ms occurred in around a third of children receiving voriconazole. They recommend ECG monitoring for all patients, and correction of electrolyte imbalances (especially potassium) before initiating voriconazole treatment.

How well is long-term fluconazole tolerated?

Safety and tolerability data for long-term use of fluconazole are scarce. Dr Davis and colleagues have published a study of 124 coccidioidomycosis patients in California and found that around half (52%) experienced significant side effects, in particular dry skin, hair loss and fatigue.

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